Genetic Institute

The Genetic Institute at Herzliya Medical Center specializes in amniocentesis, as well as ingenetic counseling and diagnosis, and is managed by one of Israel’s top medical geneticists.

The Institute features advanced equipment and a team which is skilled and experienced in all areas of genetics, thus ensuring trustworthy, highly professional and rapid service. Amniocentesis and chorionic villus sampling (CVS) exams are available for both private patients and patients eligible for the exams according to national program for prevention of congenital defects. In addition, FISH (fluorescence in situ hybridization) testing for early detection of chromosomal aberrations and DNA testing to diagnose carriers of genetic diseases are also carried out. Genetic and oncogenetic counseling for familial cancer is also available.

The Genetic Institute specializes in the diagnosis and genetic counseling of all types. The diagnostic center, with state-of-the-art laboratory, the genetic background of malignant diseases such as colon cancer, ovarian, breast, pancreatic, and more, providing genetic counseling to patients and their families. In addition, the diagnostic center traces other diseases and advise their genetic background, such as a variety of bowel diseases, patients with specific syndromes and other specific origin. 

Main Service Areas 

Breast and / or ovarian 
If it comes to breast cancer, ovary or pancreas, most cases are caused by inherited mutations in light of BRCA2 and BRCA1 genes, but there are also other syndromes which are responsible for 50% of the cases and cannot be explained by mutations of BRCA.

Colorectal cancer and multiple polyps 
Major forms of familial syndromes of gastrointestinal cancers 
The Institute identifies the causes of genetic changes in these and other syndromes and offers primary and secondary prevention for patients and their families. Early detection has immediate implications for health care planning, including medication adjustment to biological characteristics of the tumor (personalized medicine) and surgical procedures. Oncogenetic services can provide services to the world's leading multi-disciplinary health and personalized medicine for patients with various malignancies.

The Institute is active in the following fields:

  •          Cytogenetics
  •          Amniocentesis
  •          Chorionic villus sampling (CVS)
  •          FISH  / QFPCR
  •          Karyotype (chromosomal analysis)
  •          Alpha Feto Protein (AFP)

 Genetic counseling

  •          Prenatal screening results
  •          Familial genetic diseases
  •          Oncogenetics (counseling in the field of  familial cancers)

Dr. Reinstein, a graduate of the Technion Faculty of Medicine, has completed his Ph.D. in the field of biochemistry. After graduating he was appointed as a research fellow in the Department of Biology Massachusetts Institute of Technology in Boston. He has completed his internship in internal medicine at Meir Hospital, specializing in medical genetics at the University of California-Los Angeles (UCLA), USA. 

Areas of Clinical and Research: Genetics of syndromes familial cancer (breast, ovarian, colon, thyroid, pancreas, and stomach), connective tissue diseases and hereditary, aneurysm of the aorta, short stature, disease skeletal syndrome Ehlers- Danlos. 

Dr. Reinstein's works have won awards, accepted for publication in leading newspapers in genetics and presented at numerous international conferences. Dr. Reinstein is a member of the American College of Genetic Medicine (ACMG) and the American Society of Human Genetics (ASHG). 

The familial genetic diseases include: diagnosis, counseling, risk assessment, health monitoring and adjustment of treatment recommendations for patients with gastrointestinal malignancies (including multi polyps), breast, ovary, pancreas and thyroid. 
Counseling is provided to patients and their relatives. Patients and / or their family will receive advice and a high level of risk and will be recommended for making genetic investigation which involves an examination of the tumor or a DNA test. 
Genetic investigation results may assist in determining the frequency and the method of continued medical follow-up required, the necessity of taking further measures to reduce the risk and allows the detection of other family members at increased risk of getting cancer.

  • Genetic screening

 The Genetic Institute performs screening tests for 15 genetic diseases as follows:

  •     Cystic Fibrosis (CF)
  •     Mucolipidosis Type 4
  •     Fragile X Syndrome
  •     Familial Dysautonomia
  •     Gaucher's Disease
  •     Ataxia Telangiectasia (A-T)
  •     Canavan Disease
  •     Niemann-Pick
  •     Fanconi Anemia
  •     α-1-Antitrypsin Deficiency
  •     Bloom Syndrome
  •     Glycogen Storage  Disease
  •     Usher syndrome
  •     Connexin Deafness
  •     SMA
  •     Maple Syrup Urine Disease (MSUD)

Any time is suitable for these tests, including the early stages of pregnancy.

Except for Fragile-X Syndrome which has a special mode of inheritance, all the other diseases are recessive. If one person is a carrier, then the spouse must also be checked.  Only if both parents carry a mutation in the genes for the same disease, then there is a 25% chance for a sick child to be born. However, 50% of the children born will be carriers of the mutation, similarly to their parents.

All the above tests are performed on the patient's DNA using the most advanced molecular biology techniques.



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